Severe Aplastic Anemia Manifesting After Complete Remission of Acute Promyelocytic Leukemia: Is it a Fortuitous Association?
نویسندگان
چکیده
منابع مشابه
First reported case of aplastic anemia occurring in a patient after acute promyelocytic leukemia in remission.
A 32-year-old Hispanic male with a history of acute pro myelocytic leukemia (APL) in complete remission presented with increasing fatigue and mild dyspnea. His previous diagnosis of APL was made 2 years ago (Figure 1). Cytogenetic evaluation at the time of diagnosis demonstrated the presence of a reciprocal translocation between chromosomes 15 and 17, t(15;17), and the promyelocytic/retinoic ac...
متن کاملComplete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation.
Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy. However, the majority of patients with SAA are not eligible for BMT because they lack an HLA-identical sibling. Conventional immunosuppressive therapy also has major limitations; many of its remissions are incomplete and relapse or secondary clonal disease is ...
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We report a case of t(8;21) acute myeloid leukemia presenting as severe aplastic anemia. While initial bone marrow biopsy lacked any cytogenetic abnormalities in 20 analyzed metaphases, repeat bone marrow biopsy eight days later demonstrated this translocation. Initial cytogenetic analysis of 20 metaphases was therefore insufficient to make the diagnosis of hypocellular acute myeloid leukemia. ...
متن کاملAcute promyelocytic leukemia transformation in a patient with aplastic anemia: a case report with literature review.
Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with immunosuppressive therapy and granulocyte colony-stimulating factor treatment have a risk of development of acute leukemia including acute myeloid leukemia (M0, M1, M2, M4, M5, M6) and acute lymphoblastic leukemia. However, AA with transformation...
متن کاملAcute myeloid leukemia after intensive immunosuppressive therapy in aplastic anemia.
A 10-year-old boy was admitted with complaints of fever, pallor, fatigue and skin bleeds of 10 days duration and diagnosed as very severe aplastic anemia. He was given intensive immunosuppressive therapy but showed no response to therapy. He later evolved into acute myeloid leukemia. The occurrence of AML is reviewed and possible pathogenesis is discussed.
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ژورنال
عنوان ژورنال: Indian Journal of Hematology and Blood Transfusion
سال: 2012
ISSN: 0971-4502,0974-0449
DOI: 10.1007/s12288-012-0201-8